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LEAD rESEArCHEr
Forns Bernhardt, Xavier
Hospital Clínico y Provincial de Barcelona
Villarroel, 170
08036 Barcelona
[email protected]
group Website
GROUP MEMBERS
Staff members: Bonacci, Martín Sebastián | González Ferández de Córdoba, Patricia | Montero Amorós, Marta | Pérez del Pulgar Gallart, Sofía | Perpiñan Mas, Elena
Associated members: Costa Camps, Josep | Koutsoudakis, Georgios | Lens García, Sabela | Londoño Hurtado, María Carlota | Mariño Méndez, Zoe
Main lines of research
• Efficacy of new antiviral regimens against HCV and relevance of resistance-associated variants in treatment failure.
• Dynamics of resistance-associated variants during therapy with direct-acting antivirals by massive sequencing.
• Study of the innate immune response in patients with chronic hepatitis C receiving direct-acting antivirals.
• Impact of HCV elimination on the natural history of the disease.
• Natural history of chronic hepatitis C: development of predictive models of risk of progression to
cirrhosis.
• Characterization of viral and cellular factors involved in HCV infection using cell culture models in vitro.
• Molecular epidemiology and phylogenetic analysis of acute hepatitis C in HIV-coinfected patients.
• Influence of viral and host factors in the natural history and response to treatment in chronic hepatitis B.
• Molecular mechanisms and clinical significance of cccDNA persistence in HBV infection.
• Natural history of chronic HBV infection in inactive carriers and patients in the “gray zone”.
• Validation of non-invasive diagnostic methods of liver fibrosis in HBV-infected patients.
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PROGRAMMES
P3