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LEAD rESEArCHEr
Fernández-Checa Torres, José Carlos
Agencia Estatal Consejo Superior de Investigaciones Científicas
Instituto de Investigaciones Biomédicas de Barcelona C/ Rossello 161, 6a Pl. 08036 Barcelona
(+34) 93 363 83 00 [email protected] group Website
GROUP MEMBERS
Staff members: Conde de la Rosa, Laura | Núñez Pozuelo, Susana
Associated members: Caballería Rovira, Joan | García Ruiz, María del Carmen | Lluis Duquez, José María | Ribas Serra, Vicente
Main lines of research
• Contribution of lysosomal cholesterol, sphingolipids and autophagy in steatohepatitis and rare diseases.
• Development of non-invasive diagnostic methods for diagnosis and prognosis in alcohol-induced liver disease
• Hepatic cholesterol as a predictive factor for liver transplantation
• Mechanisms of ischemia/reperfusion liver injury and their regulation based on antioxidant and
antinflammatory strategies.
• Mitochondrial glutathione transporters and their implication in liver cancer
• Regulation of cholesterol homeostasis in patients and experimental models of non-alcoholic
steatohepatitis and ischemia-reperfusion injury
• Role of cholesterol in aging and Alzheimer disease
• Sphingolipid and mitochondrial oxidative-stress regulation of cell death.
• Identification of novel therapeutic targets in patients with alcoholic liver disease.
• Characterization of mechanisms involved in sorafenib cytotoxicity in hepatocellular carcinoma.
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PROGRAMMES
P1
