Page 30 - CIBEREHD2016-ENG

Bioinformatics
The Bioinformatics platform is actively cooperating in the operation of this CIBER, as shown by the 17 publications resulting from its support in 2016. Special mention should be given to the contribution made in the areas of colon cancer, specifically 4 high-impact articles in close cooperation with the group led by Dr Antoni Castells (G0016) in consortiums with (3) national and (1) international institutions. Two important publications resulting from bioinformatic analyses by massive sequencing are:
• The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. Esteban-Jurado C, Franch-Expósito S, Muñoz J, Ocaña T, Carballal S, López-Cerón M, Cuatrecasas M, Vila-Casadesús M, Lozano JJ, Serra E, Beltran S, Brea-Fernández A, Ruiz-Ponte C, Castells A, Bujanda L, Garre P, Caldés T, Cubiella J, Balaguer F, Castellví-Bel S.Eur J Hum Genet. 2016 Oct;24(10):1501-5. doi: 10.1038/ejhg.2016.44. Epub 2016 May 11.
• MicroRNAs for Detection of Pancreatic Neoplasia: Biomarker Discovery by Next-generation Sequencing and Validation in 2 Independent Cohorts. Vila-Navarro E, Vila-Casadesús M, Moreira L, Duran-Sanchon S, Sinha R, Ginés À, Fernández-Esparrach G, Miquel R, Cuatrecasas M, Castells A, Lozano JJ, Gironella M. Ann Surg. 2016.May 26. [Epub ahead of print].
It should be stressed that a project with Dr Francesc Balaguer as Principal Investigator, forming the platform as research team, under the title of Analysis of the field defect mediated by aberrant DNA methylation in the serrated polyposis syndrome, will be financed by the Instituto de Salud Carlos III in the next three yearly periods.
In the area of alcoholic hepatitis research our platform has cooperated with Dr Pau Sancho’s research team for discovery of a major microRNA biomarker involved.
• Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation. Blaya D, Coll M, Rodrigo-Torres D, Vila-Casadesús M, Altamirano J, Llopis M, Graupera I, Perea L, Aguilar-Bravo B, Díaz A, Banales JM, Clària J, Lozano JJ, Bataller R, Caballería J, Ginès P, Sancho-Bru P. Gut. 2016 Sep;65(9):1535-45.
The same area has managed to discover a new marker (KRT23) of alcoholic hepatitis after an international cooperation scheme led by Dr Ramón Bataller.
• LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. Odena G, Chen J, Lozano JJ, Altamirano J, Rodrigo-Torres D, Affo S, Morales-Ibanez O, Matsushita H, Zou J, Dumitru R, Caballeria J, Gines P, Arroyo V, You M, Rautou PE, Valla D, Crews F, Seki E, Sancho-Bru P, Bataller R.Sci Rep. 2016 Oct 18;6:35610.
In the area of hepatic haemodynamics cooperation work has been carried out, with publication in two first quartile journals. Firstly, a diagnostic tool for idiopathic portal hypertension and also describing the role of simvastatin drug in a model of biliary cirrhosis.
It should lastly be pointed out that our platform has cooperated by offering services to groups not belonging to the CIBEREHD (Dr Antonio Alcaraz) which have resulted in several publications in the first quartile. On an internal level our small group has developed and published a new bioinformatic tool (MIRComb) to study interactions between the microRNA and its target genes.
• MiRComb: An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers. Vila-Casadesús M, Gironella M, Lozano JJ.PLoS One. 2016 Mar 11;11(3):e0151127.
13203