Page 96 - CIBEREHD2016-ENG

LEAD rESEArCHEr
Martín Sanz, Paloma
Agencia Estatal Consejo Superior de Investigaciones Científicas
Instituto de Investigaciones Biomedicas Alberto Sols
C/ Arturo Duperier 4 28029 Madrid
(+34) 91 497 27 46 [email protected] group Website
GROUP MEMBERS
Associated members: Bosca Gomar, Lisardo | Casado Pinna, Marta | Mayoral Moñibas, Rafael
Main lines of research
• Dual Role of COX-2 in hepatic pathophysiology: Given the protective role of COX-2 in many of the studied diseases but also taking into account its role as inflammatory agent; it is clear that COX-2 exerts various effects depending on the time and cell type that expresses. Our goal is to further deepen this topic. For this we have transgenic animals and cell models for COX-2.
• Contribution of COX-2-dependent prostaglandins to the onset and progression of non-alcoholic fatty liver disease (NAFLD): Our results have shown that COX-2 protects against early stages of
the disease. Our goal is to advance the study evaluating the role of COX-2 in the progression to steatohepatitis and fibrosis, analyzing involved signaling pathways and molecular mechanisms, as well as the expression of COX-2 in human samples of NAFLD and its relationship with the disease.
• COX-2 and mitochondrial function. Role in ischemia reperfusion (I/R) in the liver: Our goal is to elucidate the regulation of mitochondrial function, oxidative stress and damage by I/R in response to COX-2. In this line, we analyze the correlation between levels of prostaglandins and expression of COX-2 and liver function after OLT in order to check whether the presence of prostaglandins in the graft may be a marker of prognosis in recovery of function liver in the transplanted organ.
• COX-2 and liver miRNAs: In previous studies we have shown modulation of miRNAs on the expression of COX-2 as well as the regulatory role of COX-2 itself exerts on the expression pattern of liver miRNAs involved in insulin signaling. Our interest is to continue studying the role of COX-2 in miRNAs associated with various pathologies and to search for possible mechanisms of action.
96
PROGRAMMES
P1