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Most relevant scientific articles
• Ortiz-Masia D., Cosin-Roger J., Calatayud S., Hernandez C., Alos R., Hinojosa J. et al. M1 macrophages activate notch signalling in epithelial cells: Relevance in Crohn’s disease. Journal of Crohn’s and Colitis. 2016;10(5):582-592.
• Blas-Garcia A., Marti-Rodrigo A., Victor V.M., Polo M., Alegre F., Funes H.A. et al. The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction. Journal of Antimicrobial Chemotherapy. 2016;71(4):916-926.
• Escribano-Lopez I., Diaz-Morales N., Rovira-Llopis S., de Maranon A.M., Orden S., Alvarez A. et al. The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte- endothelium interactions in leukocytes isolated from type 2 diabetic patients. Redox Biology. 2016; 10:200-205.
• Macias-Ceja D.C., Cosin-Roger J., Ortiz-Masia D., Salvador P., Hernandez C., Calatayud S. et al. The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis. Clinical Nutrition. 2016.
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy. 2016;12(1):1- 222.
Hightlights
In 2016 the group has had 6 competitive research projects underway and has been granted 3 new state- funded projects, two consolidated research group projects (FISABIO) and various young researcher contracts (two Sara Borrell, one Juan de la Cierva Formación, one Val i+d).
Members of our group participate in the “Strategic action 2016: Developing collaborative networks for basic research with human tissue in the area 2 of the CIBEREHD” Use of human tissue in translational gastroenterology research. (PI: Pere Clavé)
Two collaborations have arisen as a result of this project:
With the group led by Dr. Gisbert, Hospital La Princesa, Madrid, where Dr. Ma Dolores Ortiz Masiá received training in flow cytometry.
With the group led by Dr. Cabré, Fundación Instituto de Investigación Germans Trias i Pujol Dr. Many, Badalona, which has provided us with samples from Crohn’s patients to analyse markers of fibrosis and y macrophages.
Publication in collaboration with the CIBEREHD group led by Dr. Angel Lanas: Chueca E., Apostolova N., Esplugues J.V., Garcia-Gonzalez M.A., Lanas A., Piazuelo E. Proton pump inhibitors display antitumor effects in barrett’s adenocarcinoma cells. Frontiers in Pharmacology. 2016;7(NOV):1-1.
Inter-CIBER collaborations with the groups led by:
Dr. Ángela M. Martínez Valverde, Instituto de Investigaciones Biomédicas Alberto Sols, Madrid (CIBERDEM). Dr. Ana Blas García completed a six-month stay during which she collaborated in different projects studying the molecular mechanisms associated with non-alcoholic fatty liver disease and new therapies for this disease.
Dra. Caty Casas, del Instituto de Neurociencias de la UAB (CIBERNED).
Members of the group are part of the European Project COST Action TRANSAUTOPHAGY: European Network of Multidisciplinary Research and Translation of Autophagy Knowledge.
Dr. Nadezda Apostlova leads a NEAR (Network of Excellence for Autophagy Research) group, a national network of groups that study autophagy.
EHD
research Groups 67