Page 119 - CIBEREHD2016-ENG

Most relevant scientific articles
• Martin M., Rodriguez-Nogales A., Garces V., Galvez N., Gutierrez L., Galvez J. et al. Magnetic study on biodistribution and biodegradation of oral magnetic nanostructures in the rat gastrointestinal tract. Nanoscale. 2016;8(32):15041-15047.
• Ocon B., Aranda C.J., Gamez-Belmonte R., Suarez M.D., Zarzuelo A., Martinez-Augustin O. et al. The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice. Biochemical Pharmacology. 2016.
• Algieri F., Rodriguez-Nogales A., Garrido-Mesa J., Camuesco D., Vezza T., Garrido-Mesa N. et al. Intestinal anti-inflammatory activity of calcium pyruvate in the TNBS model of rat colitis: Comparison with ethyl pyruvate. Biochemical Pharmacology. 2016.
• Carrasco-Benso M.P., Rivero-Gutierrez B., Lopez-Minguez J., Anzola A., Diez-Noguera A., Madrid J.A. et al. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB Journal. 2016;30(9):3117-3123.
• Hidalgo-Cantabrana C., Algieri F., Rodriguez-Nogales A., Vezza T., Martinez-Camblor P., Margolles A. et al. Effect of a ropy Exopolysaccharide-producing Bifidobacterium animalis subsp. Lactis strain orally administered on dss-induced colitis mice model. Frontiers in Microbiology. 2016;7(JUN).
Hightlights
The research activity of the group has resulted in 18 articles, some of them the stemming from partnerships with other national and international research groups. It is noteworthy that most publications are framed in the first quartile, including 7 in the first decile.
Among the highlights of our research in 2016 are the following. We have established the importance of the microbiota in the intestinal inflammatory response, in terms of both immunological stimulus and input
for modulation of epithelial dynamics. We have explored the harmful effects of corticoids in experimental colitis, and a mouse conditional knock out glucocorticoid receptor model has been generated. We have characterized the distribution and degradation of magnetic nanoparticles in the murine intestine. We
have additionally studied the intestinal antiinflammatory activity of the bisphosphonate pamidronate in experimental models, as well as that of calcium pyruvate. Also, a variety of studies focused on the intestinal antiinflammatory effects of natural products, including prebiotics and probiotics, and natural extracts, has been carried out.
Our research work has been funded by several research projects, both public (MINECO, Junta de Andalucía) and private. In 2016 the group has been awarded two new national/regional projects.
EHD
research Groups 119