Page 103 - CIBEREHD2016-ENG

Most relevant scientific articles
• Aguero F., Forner A., Manzardo C., Valdivieso A., Blanes M., Barcena R. et al. Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma. Hepatology. 2016;63(2):488-498.
• Cornide-Petronio M.E., Negrete-Sanchez E., Mendes-Braz M., Casillas-Ramirez A., Bujaldon E., Merono N. et al. The Effect of High-Mobility Group Box 1 in Rat Steatotic and Nonsteatotic Liver Transplantation From Donors After Brain Death. American Journal of Transplantation. 2016.
• Aguero F., Rimola A., Stock P., Grossi P., Rockstroh J.K., Agarwal K. et al. Liver Retransplantation in Patients with HIV-1 Infection: An International Multicenter Cohort Study. American Journal of Transplantation. 2016;16(2):679-687.
• Ferrer-Fabrega J., Forner A., Liccioni A., Miquel R., Molina V., Navasa M. et al. Prospective validation of ab initio liver transplantation in hepatocellular carcinoma upon detection of risk factors for recurrence after resection. Hepatology. 2016.
Hightlights
As a consequence of the results of the different studies realized by the group in relationship with the liver graft tolerance, a new prospective, multicentre, European trial has been started to translate the results of the studies to the clinical practice. The trial (LIFT) is conducted by Dr. Alberto Sanchez-Fueyo (King’s College, London) and includes our participation.
In the field of organ retrieval and utilization of donor organs with expanded criteria, we have followed with the studies characterizing new targets based on adipocytokines modulation. We have also followed the investigation with polyethilenglycol in the preservation solutions. In addition, a new device for static preservation has been developed by Dr. Carmen Peralta, based on the control of temperature and the use of ultrasounds. Finally, in the field of dynamic preservation we are participating in a European trial and we are conducting several studies evaluating ex-vivo perfusion devices.
Three important studies have to be underlined: treatment and indications for retransplantation of coinfected patients (HIV-HVC), evaluation of the hepatorenal syndrome in patients in the wainting list for liver transplantation and the validation of the selection criteria for liver transplantation in patients with hepatocelular carcinoma.
EHD
research Groups 103