Page 19 - CIBEREHD2016-ENG

Gastrointestinal Physiopathology:
Inflammatory Disease and Motility
Disorders
Coordinator: Pere Clavé Civit
The work for 2016 in programme 2 was done in the 3 Major Research Sub-programmes in this programme and in a new transversal strategic action intended to promote cooperative research also between basic researchers in all the groups and to encourage its translation. The major active research sub-programmes are: 1) Oesophageal-gastroduodenal pathology; 2) Inflammatory bowel disease and 3) Gastrointestinal motility disorders and Neuro-gastroenterology; and the transversal action “Developing collaborative networks for basic research with human tissue”. From a quantitative angle, scientific production involved in the three major sub-programmes was highly intense; from the qualitative standpoint, the strategic transversal action has enabled us to reinforce the cooperative structure between basic researchers of
all the groups in the programme, and to reproduce in basic research the CIBEREHD success model of cooperative research.
In the oesophageal-gastroduodenal sub-programme we should stress the translation of several epidemiological, diagnostic and therapeutic studies on gastrointestinal diseases associated with Helicobacter pylori, which has enabled holding the IV Conferencia de Consenso estatal en el Tratamiento de la Infección por HP, which affects roughly 50% of the Spanish population, and the Toronto Consensus on the treatment of the infection in adults. The studies characterising gastrointestinal risk of the use of NSAIDS and the adaptation of the recommendations for use of PPI should also be highlighted, as studies with an extremely high potential for translation to clinical practice.
The Inflammatory bowel sub-programme has continued with the development of a project for cell therapy and autologous transplantation of hematopoietic progenitor cells for treatment of refractory Crohn’s disease and development of mesenchymal stem cells for treatment of fistulising perianal disease. On the physiopathological side we should emphasise: a) studies on the relevance of the macrophagic phenotype in human and murine colitis and the role of autophagy in the intestinal epithelial cell; b) the importance
of the microbiota in the intestinal inflammatory response, in its dual aspect of source of immunological stimulation and regulation of epithelial dynamics; and c) by means of studies based on using organoids
it has been shown that there are permanent changes in the epithelium of patients with ulcerous colitis, which are conditioned by disorders in the conduct of intestinal stem cells and which could contribute to perpetuating the disease. The groups have also provided significant contributions to improving clinical practice by taking part in writing the clinical guide of the European Crohn’s and Colitis Organization on the use of biosimilar medications.
The work done in 2016 in the sub-programme on motility disorders and neurogastroenterology including the development of a sensorial neuromodulation protocol for treatment of oropharyngeal dysphagia after strokes; the development and validation by means of a pilot study of “Minimum-Massive Interventions” enabling reducing readmissions through respiratory nutritional complication in the elderly with dysphagia at General Hospitals, We have contributed to the development of two systematic reviews establishing clinical guides for handling Dysphagia after two years of interaction between two European scientific associations (ESSD/EUGMS), and which recognise oropharyngeal dysphagia as a geriatric syndrome and establish the bases for the treatment. Groups in the programme have contributed to the development of Rome IV Criteria for diagnosis of functional digestive disorders. Lastly, the implementation of the Strategic Action entitled Networks for Basic Research with Human Tissue in the Area 2 of the Ciberehd has enabled three young CIBER researchers to lead and develop a network of 18 cooperative projects in basic research of the programme.
EHD
Scientific programmes 19