Page 100 - CIBEREHD2016-ENG

LEAD rESEArCHEr
Mato de la Paz, José María
CIC BIOGUNE
Parque Tecnológico de Bizkaia Edificio 800
48160 Derio
(+34) 946572517 [email protected] group Website
GROUP MEMBERS
Staff members: Fernández Ramos, David | Royo López, Félix Miguel | Varela Rey, Marta
Associated members: Abrescia, Nicola Gerardo | Aransay Bañares, Ana María | Elortza Basterrika, Felix | Falcón Pérez, Juan Manuel | Martínez Chantar, María Luz
Main lines of research
At present, the aim of our work is to study metabolic alterations as a tool and target for the detection, prevention and treatment of nonalcoholic steatohepatitis (NASH) including its progression to liver cirrhosis and cancer. To this end, we utilize state-of-the-art metabolomic, proteomics, genomic, structural biology and molecular imaging technologies together with biological systems of increasing complexity, including cellular systems, genetic engineered mouse models and human prospective studies. The specific areas of research are:
• We investigate the regulation of S-adenosylmethionine (SAMe) biosynthesis in mammalian cells and the
function of SAMe in fatty liver disease, liver cirrhosis, and cancer.
• New molecular mechanisms in the development and progression of nonalcoholic fatty liver disease
(NAFLD) to liver cancer: unraveling the impact of the post-translational modifications.
• Application of “omics” technologies to the study of the composition and function of hepatic exosomes:
application to the identification of new noninvasive biomarkers of liver diseases.
• Structural virology of envelope and lipid-containing viruses: host-recognition and assembly.
• We offer state-of-the-art technological services in genomics, proteomics and metabolomics to all members
of CIBEREHD.
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PROGRAMMES
P1